Friday, 28 August 2015

Silicon Valley -world's largest high-tech corporations,


Silicon Valley is a nickname for the southern portion of the San Francisco Bay Area, which is located in the part of the U.S. state of California known as Northern California. It is home to many of the world's largest high-tech corporations, as well as thousands of tech startup companies. The word "valley" refers to the Santa Clara Valley where the region has traditionally been centered, which includes the city of San Jose and surrounding cities and towns. The word "silicon" originally referred to the large number of silicon chip innovators and manufacturers in the region. The term "Silicon Valley" eventually came to refer to all high tech businesses in the area, and is now generally used as a metonym for the American high-technology economic sector.


Silicon Valley is a leading hub and startup ecosystem for high-tech innovation and development, accounting for one-third of all of the venture capital investment in the United States. Geographically, Silicon Valley is generally thought to encompass all of the Santa Clara Valley, San Francisco, the San Francisco Peninsula, and southern portions of the East Bay.

The term Silicon Valley is attributed to Ralph Vaerst, a local entrepreneur. Its first published use is credited to Don Hoefler, a friend of Vaerst's, who used the phrase as the title of a series of articles in the weekly trade newspaper Electronic News. The series, entitled "Silicon Valley in the USA", began in the paper's January 11, 1971, issue. The term gained widespread use in the early 1980s, at the time of the introduction of the IBM PC and numerous related hardware and software products to the consumer market. The Silicon part of the name refers to the high concentration of companies involved in the making of semiconductors (silicon is used to create most semiconductors commercially) and computer industries that were concentrated in the area. These firms slowly replaced the orchards and related agriculture and food production companies which gave the area its initial nickname — the "Valley of Heart's Delight."

Stanford University, its affiliates, and graduates have played a major role in the development of this area. Some examples include the work of Lee De Forest with his invention of a pioneering vacuum tube called the Audion and the oscilloscopes of Hewlett-Packard.

A very powerful sense of regional solidarity accompanied the rise of Silicon Valley. From the 1890s, Stanford University's leaders saw its mission as service to the West and shaped the school accordingly. At the same time, the perceived exploitation of the West at the hands of eastern interests fueled booster-like attempts to build self-sufficient indigenous local industry. Thus, regionalism helped align Stanford's interests with those of the area's high-tech firms for the first fifty years of Silicon Valley's development.
During the 1940s and 1950s, Frederick Terman, as Stanford's dean of engineering and provost, encouraged faculty and graduates to start their own companies. He is credited with nurturing Hewlett-Packard, Varian Associates, and other high-tech firms, until what would become Silicon Valley grew up around the Stanford campus. Terman is often called "the father of Silicon Valley".

In 1956 William Shockley, the creator of the transistor, moved from New Jersey to Mountain View, California, to start Shockley Semiconductor Laboratory to live closer to his ailing mother in Palo Alto. Shockley's work served as the basis for many electronic developments for decades.

During 1955–85, solid state technology research and development at Stanford University followed three waves of industrial innovation made possible by support from private corporations, mainly Bell Telephone Laboratories, Shockley Semiconductor, Fairchild Semiconductor, and Xerox PARC. In 1969, the Stanford Research Institute (now SRI International), operated one of the four original nodes that comprised ARPANET, predecessor to the Internet.
Silicon Valley has a social and business ethos that supports innovation and entrepreneurship. Attempts to create "Silicon Valleys" in environments, such as Europe, where disruptive innovation does not go over well have a poor track record.

According to a 2008 study by AeA in 2006, Silicon Valley was the third largest high-tech center (cybercity) in the United States, behind the New York metropolitan area and Washington metropolitan area, with 225,300 high-tech jobs. The Bay Area as a whole however, of which Silicon Valley is a part, would rank first with 387,000 high-tech jobs. Silicon Valley has the highest concentration of high-tech workers of any metropolitan area, with 285.9 out of every 1,000 private-sector workers. Silicon Valley has the highest average high-tech salary at $144,800.Largely a result of the high technology sector, the San Jose-Sunnyvale-Santa Clara, CA Metropolitan Statistical Area has the most millionaires and the most billionaires in the United States per capita.

The region is the biggest high-tech manufacturing center in the United States.The unemployment rate of the region was 9.4% in January 2009, up from 7.8% in the previous month. Silicon Valley received 41% of all U.S. venture investment in 2011, and 46% in 2012.

Manufacture of transistors is, or was, the core industry in Silicon Valley. The production workforce was for the most part composed of Asian and Latina female immigrants who were paid low wages and worked in hazardous conditions due to the chemicals used in the manufacture of integrated circuits. Technical, engineering, design, and administrative staffs were in large part male and well compensated.

Many more jobs are created in Silicon Valley then there are houses built. Housing prices are extremely high, far out of the range of production workers

Lionel Andrés "Leo" Messi Cuccittini -Argentine professional footballer

Lionel Andrés "Leo" Messi Cuccittini ; born 24 June 1987) is an Argentine professional footballer who plays for Spanish club FC Barcelona and the Argentina national team as a forward, and is also the captain of the national team.
2015 UEFA Super Cup 64 crop.jpg
By the age of 21, Messi had received Ballon d'Or and FIFA World Player of the Year nominations. The following year, in 2009, he won his first Ballon d'Or and FIFA World Player of the Year awards. He followed this up by winning the inaugural FIFA Ballon d'Or in 2010, and then again in 2011 and 2012. He also won the UEFA Best Player in Europe Award twice, in 2011 and 2015. At the age of 24, Messi became Barcelona's all-time top scorer in all official club competitions. In September 2014 he scored his 400th senior career goal for club and country aged just 27. In November 2014, Messi became the all-time top scorer in La Liga, and the all-time leading goalscorer in the UEFA Champions League.
Often considered the best player in the world and rated by some in the sport as the greatest of all time, Messi is the first and only football player in history to win four FIFA/Ballons d'Or, all of which he won consecutively, and the first to win three European Golden Shoe awards. With Barcelona, Messi has won seven La Ligas, three Copas del Rey, six Supercopas de España, four UEFA Champions Leagues, three UEFA Super Cups and two FIFA Club World Cups.

Messi is the only player to top-score in four consecutive Champions League seasons, and also holds the record for the most hat-tricks scored in the competition with five. In March 2012, he made Champions League history by becoming the first player to score five goals in one match. In the 2011–12 season, Messi set the European record for most goals scored in a season with 73 goals, set the goalscoring record in a single La Liga season with 50 goals, and became the second player ever to score in six different official competitions in one season after Pedro.In February 2013 he scored his 300th Barcelona goal. On 30 March 2013, Messi scored in his 19th consecutive La Liga game, becoming the first footballer in history to net in consecutive matches against every team in a professional football league. He extended his record scoring streak to 21 consecutive league matches. In March 2014, with a hat-trick against Real Madrid, Messi became the player with the most goals and most hat-tricks in the history of El Clásico. In October 2014, Messi, aged 27, became the youngest player to score 250 goals in La Liga. In November 2014, Messi scored a hat-trick against Sevilla to reach 253 La Liga goals, becoming the all-time top scorer in La Liga. In May 2015, he scored his 77th Champions League goal to become its all-time leading scorer.
Messi helped Argentina win the 2005 FIFA U-20 World Cup, finishing as both the best player and the top scorer (with six goals). In 2006, he became the youngest Argentine to play and score in the FIFA World Cup, and in 2007 he won a runners-up medal at the Copa América, in which he was named young player of the tournament. In 2008, he won an Olympic Gold Medal with the Argentina Olympic football team. At the 2014 World Cup, he led Argentina to the final, winning four consecutive Man of the Match awards in the process, and received the Golden Ball award as the best player of the tournament. In 2013, SportsPro rated him the second-most marketable athlete in the world.In 2015, he won a second runners-up medal at the Copa América; he also took part in the 2010 World Cup and the 2011 Copa América with his national side. His playing style and stature have drawn comparisons to compatriot Diego Maradona, who himself declared Messi his "successor".Messi was born on 24 June 1987 in Rosario, Santa Fe Province, to parents Jorge Horácio Messi, a factory steel worker, and Celia María Cuccittini, a part-time cleaner.His paternal great-grandfather, Angelo Messi originates from the Italian city of Recanati and emigrated to Argentina in 1883. He has two older brothers, Rodrigo and Matías, and a sister, María Sol.At the age of five, Messi started playing football for Grandoli, a local club coached by his father Jorge. In 1995, Messi switched to Newell's Old Boys who were based in his home city Rosario. He became part of a local youth team that lost only one match in the next four years and became locally known as "The Machine of '87", the year of their birth.
At the age of 11, Messi was diagnosed with a growth hormone deficiency. Local team River Plate showed interest in Messi's progress, but were not willing to pay for treatment for his condition, which cost $900 a month. Carles Rexach, the sporting director of FC Barcelona, was made aware of his talent as Messi had relatives in Lleida in western Catalonia, and Messi and his father were able to arrange a trial with the team. Rexach, with no other paper at hand, offered Messi a contract written on a paper napkin. Barcelona offered to pay Messi's medical bills on the condition that he moved to Spain. Messi and his father duly moved to Barcelona, where Messi enrolled in the club's youth academy.
Messi was at one stage romantically linked to Macarena Lemos, also from his hometown of Rosario. He is said to have been introduced to her by the girl's father when he returned to Rosario to recover from his injury a few days before the start of the 2006 World Cup. He has in the past also been linked to the Argentine glamour model Luciana Salazar.
In January 2009, he told "Hat Trick Barça", a programme on Canal 33: "I have a girlfriend and she is living in Argentina. I am relaxed and happy". He was seen with the girl, Antonella Roccuzzo,at a carnival in Sitges after the Barcelona-Espanyol derby. Roccuzzo is a fellow native of Rosario. On 2 June 2012, Messi assisted and scored a goal in Argentina's 4–0 win against Ecuador in a World Cup 2014 Qualifying match. He celebrated scoring his 23rd goal for Argentina, by placing the ball under his jersey, as his girlfriend was reportedly 12 weeks pregnant. She posted on Twitter that she expected to give birth in September. Messi stated that the child, a son, would be born in October, and that he and his girlfriend would name him Thiago.

However, the birth came later than expected. On 2 November 2012, Messi became a father for the first time following the birth of his son Thiago. FC Barcelona's official website briefly stated "Leo Messi is a father". Furthermore, the Argentine striker added on his Facebook page: "Today I am the happiest man in the world, my son was born and thanks to God for this gift!" He also had the boy's name and handprints tattooed on his left calf.

To celebrate his son's first birthday, Messi and Thiago were part of a publicity campaign for UNICEF. Those who signed up and participated in the social-media campaign had the chance to win a pair of Messi's shoes or a signed Messi T-shirt.

Messi has two cousins also involved in football: brothers Maxi and Emanuel Biancucchi, who play for Brazil's Bahia.

In 2013, Messi, a devout Roman Catholic, met Pope Francis, himself a fan of Argentine club San Lorenzo, at the Vatican, with Messi stating; “Without a doubt, today was one of the most special days of my life. We have to excel on and off the field.”

Messi has maintained close ties to Rosario and his family since leaving for Spain, and has gone to great lengths to maintain them. He keeps in daily contact via phone and text with a small group of confidants from Rosario, most of them fellow members of "The Machine of '87". One time when he was in training with the Argentina national team in Buenos Aires, he made a three-hour trip by car to Rosario immediately after practice to have dinner with his family, spent the night with them, and then returned to Buenos Aires the next day in time for practice. Messi has also kept ownership of his old house in Rosario, although his family no longer lives in it; he maintains a penthouse apartment in an exclusive residential building in which his mother lives (Messi's father spends most of his time in Spain with him), as well as a family compound just outside the city.

Marcy Borders -"The dust lady".

Marcy Borders.jpg
Marcy Borders (died August 24, 2015) was a bank clerk, who worked in the World Trade Center and survived its collapse, following al Qaeda attacks on September 11, 2001.Stan Honda, a photographer for Agence France Presse, captured an image of Borders, completely covered in dust from the building collapse, that subsequently became widely described as "iconic". The image became so well-known and so widely distributed, that Borders became known as "the dust lady".

Borders had only been working at the World Trade Center for four weeks prior to the attack.According to the "The Routledge Companion to UK Counter-Terrorism", Borders said that she never recovered from the trauma of the attack. Depression led to a break-up from her partner, losing custody of her children, and several addictions.

Borders said that a key event in her recovery and return to sobriety was learning of the death of Osama bin Laden.

Borders had preserved the outfit she wore in the iconic photo, without removing any of the dust.The image Honda took of Borders was iconic; she was remembered in many retrospective articles about the attacks of 9/11.The Telegraph chose her as one of the survivors they profiled on the tenth anniversary of the attack. Borders had been invited to spend the tenth anniversary of 9/11 at a memorial event in Germany.Borders was diagnosed with stomach cancer in August 2014.

Borders's cancer had already saddled her with a crippling debt of $190,000—even though she had not yet received surgery and she still needed additional chemotherapy. Borders said she could not even afford to get her prescriptions filled.

Borders died from cancer on August 24, 2015. She believed her cancer was triggered by the toxic dust she was exposed to when the WTC collapsed. Her death was very widely reported.Borders and Sharbat Gula are the two main characters of Pamela Booker's 2009 play "Dust: Murmurs and a play". Both Borders and Gula first became known to the public through iconic photos. Booker dedicated her play to Borders and Gula.

Thursday, 27 August 2015

Christiaan Neethling Barnard -world's first successful human-to-human heart transplant

Christiaan Neethling Barnard (8 November 1922 – 2 September 2001) was a South African cardiac surgeon who performed the world's first successful human-to-human heart transplant.Barnard grew up in Beaufort West, Cape Province, Union of South Africa. His father, Adam Barnard, was a minister in the Dutch Reformed Church.One of his four brothers, Abraham, died of a heart problem at the age of five. Barnard matriculated from the Beaufort West High School in 1940, and went to study medicine at the University of Cape Town Medical School, where he obtained his MB ChB in 1945.

Barnard did his internship and residency at the Groote Schuur Hospital in Cape Town, after which he worked as a general practitioner in Ceres, a rural town in the Cape Province. In 1951, he returned to Cape Town where he worked at the City Hospital as a Senior Resident Medical Officer, and in the Department of Medicine at the Groote Schuur Hospital as a registrar.He completed his Master's degree, receiving Master of Medicine in 1953 from the University of Cape Town. In the same year he obtained a doctorate in medicine (MD) from the same university for a dissertation titled "The treatment of tuberculous meningitis".


In 1956, he received a two-year scholarship for postgraduate training in cardiothoracic surgery at the University of Minnesota, Minneapolis, United States under open-heart surgery pioneer Walt Lillehei. It was during this time that Barnard first became acquainted with fellow future heart transplantation surgeon Norman Shumway, who along with Richard Lower did much of the trailblazing research leading to the first successful human heart transplant. In 1958 he received a Master of Science in Surgery for a thesis titled "The aortic valve – problems in the fabrication and testing of a prosthetic valve". The same year he was awarded Doctor of Philosophy degree for his dissertation titled "The aetiology of congenital intestinal atresia". Barnard described the two years he spent in the United States as "the most fascinating time in my life."

Upon returning to South Africa in 1958, Barnard was appointed cardiothoracic surgeon at the Groote Schuur Hospital, establishing the hospital's first heart unit. He was promoted to full-time lecturer and Director of Surgical Research at the University of Cape Town. In 1960, he flew to Moscow in order to meet Vladimir Demikhov, a top expert on organ transplants. In 1961 he was appointed Head of the Division of Cardiothoracic Surgery at the teaching hospitals of the University of Cape Town. He rose to the position of Associate Professor in the Department of Surgery at the University of Cape Town in 1962. Barnard's younger brother Marius, who also studied medicine, eventually became Barnard's right-hand man at the department of Cardiac Surgery.Over time, Barnard became known as a brilliant surgeon with many contributions to the treatment of cardiac diseases, such as the Tetralogy of Fallot and Ebstein's anomaly. He was promoted to Professor of Surgical Science in the Department of Surgery at the University of Cape Town in 1972. Among the many awards he received over the years, he was named Professor Emeritus in 1984.
Following the first successful kidney transplant in 1953, in the United States, Barnard performed the second kidney transplant in South Africa in October 1967, the first being done in Johannesburg the previous year.Barnard experimented for several years with animal heart transplants. More than 50 dogs received transplanted hearts. With the availability of new breakthroughs introduced by several pioneers, amongst them Norman Shumway, several surgical teams were in a position to prepare for a human heart transplant.Barnard had a patient willing to undergo the procedure, but as with other surgeons, he needed a suitable donor.

He performed the world's first human heart transplant operation on 3 December 1967, in an operation assisted by his brother, Marius Barnard; the operation lasted nine hours and used a team of thirty people The patient, Louis Washkansky, was a 54-year-old grocer, suffering from diabetes and incurable heart disease. Barnard later wrote, "For a dying man it is not a difficult decision because he knows he is at the end. If a lion chases you to the bank of a river filled with crocodiles, you will leap into the water, convinced you have a chance to swim to the other side." The donor heart came from a young woman, Denise Darvall, who had been rendered brain damaged in an accident on 2 December 1967, while crossing a street in Cape Town. After securing permission from Darvall's father to use her heart, Barnard performed the transplant. Rather than wait for Darvall's heart to stop beating, at his brother, Marius Barnard's urging, Christiaan had injected potassium into her heart to paralyse it and render her technically dead by the whole-body standard. Twenty years later, Marius Barnard recounted, "Chris stood there for a few moments, watching, then stood back and said, 'It works.'" Washkansky survived the operation and lived for 18 days. However, he succumbed to pneumonia as he was taking immunosuppressive drugs. Though the first patient with the heart of another human being survived for only a little more than two weeks, Barnard had passed a milestone in a new field of life-extending surgery.

Barnard was celebrated around the world for his accomplishment. He was photogenic, and enjoyed the media attention following the operation. Barnard continued to perform heart transplants. A transplant operation was conducted on 2 January 1968, and the patient, Philip Blaiberg, survived for 19 months. Dirk van Zyl, who received a new heart in 1971, was the longest-lived recipient, surviving over 23 years.

Barnard performed ten orthotopic transplants (1967–1973). He was also the first to perform a heterotopic heart transplant, an operation that he devised. Forty-nine consecutive heterotopic heart transplants were performed in Cape Town between 1975 and 1984.

Many surgeons gave up cardiac transplantation due to poor results, often due to rejection of the transplanted heart by the patient's immune system. Barnard persisted until the advent of ciclosporin, an effective immunosuppressive drug, which helped revive the operation throughout the world. He was also the first surgeon to attempt xenograft transplantation in a human patient, while attempting to save the life of a young girl unable to leave artificial life support after a second aortic valve replacement.
Barnard was an outspoken opponent of South Africa's laws of apartheid, and was not afraid to criticise his nation's government, although he had to temper his remarks to some extent to travel abroad. Rather than leaving his homeland, he used his fame to campaign for a change in the law. Christiaan's brother, Marius Barnard, went into politics, and was elected to the legislature on an anti-apartheid platform. Barnard later stated that the reason he never won the Nobel Prize in Physiology or Medicine was probably because he was a "white South African.
Barnard's first marriage was to Aletta Gertruida Louw, a nurse, whom he married in 1948 while practising medicine in Ceres. The couple had two children — Deirdre (born 1950) and Andre (1951–1984). International fame took a toll on his personal life, and in 1969, Barnard and his wife divorced. In 1970, he married heiress Barbara Zoellner when she was 19, and they had two children — Frederick (born 1972) and Christiaan Jr. (born 1974). He divorced Zoellner in 1982.Barnard married for a third time in 1988 to Karin Setzkorn, a young model. They also had two children, Armin (born 1990) and Lara (born 1997), but this last marriage also ended in divorce in 2000.

Barnard had extramarital affairs with film star Gina Lollobrigida.
Christiaan Barnard wrote two autobiographies. His first book, One Life, was published in 1969 and sold copies worldwide. Some of the proceeds were used to set up the Chris Barnard Fund for research into heart disease and heart transplants in Cape Town. His second autobiography, The Second Life, was published in 1993, eight years before his death.

Apart from his autobiographies, Dr Barnard also wrote several other books including:

The Donor
Your Healthy Heart
In The Night Season
The Best Medicine
Arthritis Handbook: How to Live With Arthritis
Good Life Good Death: A Doctor's Case for Euthanasia and Suicide
South Africa: Sharp Dissection
50 Ways to a Healthy Heart
Body Machine